Halfway between the Charles bridge and Národní třída, you will find a café I very much recommend visiting. It is called Krásný ztráty and it has become quite popular here – so famous in fact, that a regular TV talkshow used to be recorded there. Krásný ztráty is a place where a lot of interesting people gather. It is one of the few places where you can find students, intellectuals and celebrities all at once.
Although it is called a café, once again it has the character of a regular restaurant. They cook all day and the food is great while prices remain moderate. I can particularly recommend visiting for a breakfast or a brunch as Krásný ztráty is a calm place with a very nice interior design.
Apart from being a café, a bar and a restaurant, Krásný ztráty is also a wine shop, a book shop, a gallery and an occasional music club or theatre stage. There are many events taking place there so you might want to check that out at their website.
A perfect place downtown for an informal work meeting!